On October 26, 1881, Holliday was deputized by Tombstone city marshal Virgil Earp. The lawmen attempted to disarm five members of the Cowboys near the O.K. Corral on the west side of town, which resulted in the famous shootout.

Following the Tombstone shootout, Virgil Earp was maimed by hidden assailants while Morgan Earp was killed. Unable to obtain justice in the courts, Wyatt Earp took matters into his own hands. As the recently appointed deputy U.S. marshal,