that results in a 50% decrease in consumption is considered the IC₅₀ for fluid consumption of that drug.

Functional antagonist assay

The IC₅₀ of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC₅₀ values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response

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