Natick, Massachusetts, purchasing additional buildings in the complex in 2008 and 2009, ultimately occupying the entire campus. MathWorks expanded further in 2013 by buying Boston Scientific's old headquarters campus, which is near to MathWorks' headquarters in Natick.

By 2018, the company had around 3,000 employees in Natick and said it had revenues of around $900 million.

On May 18, 2025, MathWorks was the target of a ransomware attack which took

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