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<p>shape, size, protein composition, and texture of the nucleus are often altered in <a href="page.php?w=malignant_cells">malignant cells</a>. The nucleus may acquire grooves, folds or indentations, <a href="page.php?w=chromatin">chromatin</a> may aggregate or disperse, and the <a href="page.php?w=nucleolus">nucleolus</a> can become enlarged. In normal cells, the nucleus is often round or solid in shape, but in cancer cells the outline is often irregular. Different combinations of abnormalities are characteristic of different cancer types, to the</p><p>
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