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<p>the <a href="page.php?w=gene">gene</a> was cloned in 1989, and the first <a href="page.php?w=knockout_mouse">knockout mouse</a> was created in 1996. The function of desmin has been deduced through studies in knockout mice. Desmin is one of the earliest protein markers for muscle tissue in embryogenesis as it is detected in the <a href="page.php?w=somite">somite</a>s. Although it is present early in the development of muscle cells, it is only expressed at low levels, and increases as the cell nears terminal differentiation. A similar protein,</p><p>
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