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mutations is variable from gene-to-gene and tissue-to-tissue, but gene silencing occurs in every patient with a nonsense mutation.

Simple example

DNA: 5´--ATG ACT CAC CGA GCG CGA AGC TGA--3´ 3´--TAC TGA GTG GCT CGC GCT TCG ACT--5´
mRNA: 5´--AUG ACU CAC CGA GCG CGA AGC UGA--3´
Protein: N--Met Thr His Arg Ala Arg Ser Stop--C

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