domain made of seven WD40 repeats, that forms a ?-propeller, found in its C-terminal part. Polymorphisms and mutations in these domains are considered to be associated with several diseases.

Due to present models, ATG16L1 is supposed to exist in ~800 kDa complexes which contain ATG12-ATG5 and several ATG16L1 dimers. These dimers are composed mostly of a CCD region of the protein and ATG5 binding site. The middle region