were first identified in 1991 by single-channel recordings of the inner mitochondrial membrane. The molecular structure of mitoK_ATP is less clearly understood than that of sarcK_ATP. Some reports indicate that cardiac mitoK_ATP consist of K_ir6.1 and K_ir6.2 subunits, but neither SUR1 nor SUR2. More recently, it was discovered that certain multiprotein complexes containing succinate dehydrogenase can provide activity similar to that of K_ATP channels.

The presence of nucK_ATP