Immunosuppressive drugs that inhibit T cell activation have been effective in treating severe cases of chronic guttate psoriasis. Due to the role streptococcal infection plays in the development of guttate psoriasis, systemic antibiotics have been considered as a potential treatment option. There is uncertain evidence whether systemic antibiotics or tonsillectomy are effective and safe in treating the disease. The condition often clears up on its own within weeks to months.

Guttate psoriasis tends to follow two patterns of progression: