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<p><a href="page.php?w=opperhoofd">opperhoofd</a>, or chief <a href="page.php?w=Factor_%28agent%29">factor</a>, in Japan from 1779 to 1780, from 1781 to 1783, and again in 1784. The singular importance of the head of the VOC in Japan during this period was enhanced by the Japanese policy of <a href="page.php?w=Sakoku">Sakoku</a>, the self-imposed isolation of Japan that lasted from 1633 to 1853. Because of religious proselytizing by Europeans during the 16th century, the Tokugawa shogunate introduced a policy in the early 17th century that no European</p><p>
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