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<p>intestinal crypts house <a href="page.php?w=stem_cells">stem cells</a> that serve to constantly replenish <a href="page.php?w=epithelial_cells">epithelial cells</a> that die and are lost from the <a href="page.php?w=Intestinal_villus">villi</a>. Paneth cells support the physical barrier of the epithelium by providing essential niche signals to their neighboring <a href="page.php?w=intestinal_stem_cells">intestinal stem cells</a>. Protection and stimulation of these <a href="page.php?w=stem_cells">stem cells</a> is essential for long-term maintenance</p><p>
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