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and function during simian immunodeficiency virus (SIV) infection. This pathway can potentially be targeted to enhance killing of HIV infected cells during "Shock and Kill" HIV curative approaches.

Cancer

TIGIT and PD-1 has been shown to be over-expressed on tumor antigen-specific (TA-specific) CD8⁺ T cells and CD8⁺ tumor infiltrating lymphocytes (TILs) from individuals

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