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mice showed impaired activation of inflammasome components, such as caspase-1, and reduced levels of IL-1? and IL-18, highlighting its critical role in antiviral defense.

Structure

ZBP1 has several key domains that contribute to its function. At the N-terminus, it has Z-nucleic acid (Z-NA) binding domains, known as Z?1 and Z?2. Both Z? domains have a winged helix-turn-helix

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