1.Previous
3.Next

using a predefined molar ratio of 1:2:1, respectively, leading to a piperidone. Additionally, a second condensation between the piperidone, an aliphatic aldehyde and a primary amine, using a ratio of 1:4:2, yields the desired bispidine. The reaction conditions need to be controlled to avoid the competitive aldol reaction. Indeed the reaction solution should be as concentrated as possible to afford maximum yield, using alcohols,

1.Previous
3.Next