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(GORD or GERD)
* Erosive esophagitis
* Part of a multidrug regimen for Helicobacter pylori eradication to minimise the risk of duodenal ulcer recurrence
* Recurrent postoperative ulcer
* Upper GI bleeding
* For prevention of acid-aspiration pneumonitis during surgery, it can be administered preoperatively. The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis

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