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<p><big>Clinical significance</big></p>
<p><big>Rupture</big></p>
<p>Rupture of the anterior cruciate ligament is one of the "most frequent acquired diseases of the <a href="page.php?w=stifle_joint">stifle joint</a>" in humans, dogs, and cats; direct trauma to the joint is relatively uncommon and age appears to be a major factor.</p>

<p>Cruciate ligament injuries are common in animals, and in 2005 a study estimated that $1.32 billion was spent in the United States in treating the cranial cruciate ligament of dogs.</p>

<p><big>Rupture in canines and surgical repair techniques</big></p><p>
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