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increase in intracellular calcium. In multicellular organisms, this mechanism initiates many forms of intercellular communication such as synaptic transmission, hormone secretion by neuroendocrine cells, and immune cells' secretion. In neurons and endocrine cells, the SNARE proteins and SM-proteins catalyze the fusion by forming a complex that brings the two fusion membranes together. For instance, in synapses, the SNARE complex is formed by syntaxin-1

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