"De rerum natura" (On the Nature of Things) available to scholars, all but three contain marginal notes.

The practice of writing in the margins of books gradually declined over several centuries after the invention of the printing press. Printed books gradually became much less expensive, so they were no longer regarded as long-term assets to be improved for succeeding generations. The first Gutenberg Bible was printed in the 1450s. Hand annotations occur in most surviving books through the end of the 1500s. Marginalia did not become