The seat of Praefectus legionis septimae Claudiae was in the frontier fortress of Cuppae (Golubac, Serbia).

As a frontier province, Moesia Prima was under constant threat of barbaric invasions. In the middle of the 5th century the province was devastated by the Huns of Attila who took Singidunum and Viminacium in 441. The province was later invaded by various Germanic tribes