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they suppress the anti-tumor immune response. The presence of MDSCs has been associated with progression of colon cancer, tumor angiogenesis, and metastases. In addition to producing NO and ROS, MDSCs secrete immune-regulatory cytokines such as TNF, , and . There are subpopulations of MDSC that have some common suppressive characteristics but also have their own unique features; different subpopulations can be found

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