On 21 December 1988, 340 g (12 ounces) of Semtex brought down a Boeing 747 over Lockerbie, Scotland killing all 259 passengers and crew aboard the aircraft and 11 bystanders on the ground.

Sales declined after Semtex became closely associated with terrorist attacks. Rules governing the explosive's export were progressively tightened over the years, and since 2002 all of Explosia's trading has been controlled by a government ministry. as of 2001, only approximately 10 tons of Semtex were produced