and Nashville Railroad did. (All odd-numbered U.S. Highways are north-south routes: e.g. U.S. 1, 11, 21, 31, 41, 51, 61, and 71, 101, going from East to West) The eastern part of Shelby County was later crossed by U.S. Highway 231 and U.S. 280.

Decades later, Shelby County was crossed by Interstate Highway 65. Hence, an important ingredient in the eventual growth of Shelby County