while working for the Monsanto Company he developed an enantioselective hydrogenation step for the production of L-DOPA, utilising the DIPAMP ligand.

Personal life

Following his retirement in 1986, Knowles resided in Chesterfield, Missouri, a suburb of St. Louis. In retirement he restored native prairie grasses on a 100-acre farm that his wife had inherited. He was married to his wife, Nancy, for 66 years and had

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