talin components of the integrin-vinculin-talin complex are cytoskeletal proteins physically anchored to the costamere as a whole via the integrin components, which are transmembrane proteins that interact directly with filamin C of the Z disk.

Function

Costameres have several primary functions. First, they keep the sarcolemma in line with the sarcomere during contraction and subsequent relaxation. They are also responsible for the lateral transmission of the sarcomere-generated contractile force to the sarcolemma and the extracellular matrix.

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