animal models with SNc lesions. Thus, electrical stimulation of the substantia nigra does not result in movement, but lack of pars compacta neurons has a large influence on movement, as evidenced by the symptoms of Parkinson's disease.

Pathology

Degeneration of pigmented neurons in this region is the principal pathology that underlies Parkinson's disease and this depigmentation can be visualized in vivo with Neuromelanin MRI. In a few people, the

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