A nacreous pearl is made from layers of nacre, by the same living process as is used in the secretion of the mother of pearl, which lines the shell.

Natural (or wild) pearls, formed without human intervention, are very rare. Many hundreds of pearl oysters or mussels must be gathered and opened, and thus killed, to find even one wild pearl; for many centuries, this was the only way pearls were obtained, and why pearls fetched such extraordinary prices in the past.