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<p>In these so-called <a href="page.php?w=clathrate">clathrate</a>s, the organic "guest" molecules are held in channels formed by interpenetrating helices composed of <a href="page.php?w=hydrogen_bond">hydrogen-bonded</a> urea molecules.  In this way, urea-clathrates have been well investigated for separations.</p>

<p><big>Reactions</big></p>
<p><big>Basicity</big></p>
<p>Urea is a weak base, with a pK of 13.9. When combined with strong acids, it undergoes protonation at oxygen to form <b>uronium</b> salts. It is a <a href="page.php?w=Lewis_base">Lewis base</a>,</p><p>
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