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Although the fundamental structure of mature VWF is monomeric, the smallest form detectable in blood plasma is a VWF dimer.

The basic monomer of VWF, a 2050-amino-acid protein, contains several key domains with specific functions:

* The D'/D3 domain: Binds to factor VIII, heparin, and P-selectin.
* The A1 domain: Binds to the platelet GPIb-receptor, collagen types IV and VI, heparin,

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