to Crohn's disease. A coding polymorphism in ATG16L1 gene is considered to be a risk factor for Crohn's disease development as well as ATG16L2. ATG16L1 appears to be an essential protein for the function of intestinal stem cells, morphological structure of intestinal cells and granule exocytosis pathway of the Paneth cells in animal models.

Bacteria invasion leads to ATG16L1 recruiting by NOD1 and