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of Perdiccas, regent of Alexander's designated successor. Shortly thereafter, Atropates refused to pay allegiance to Seleucus, and made Media Atropatene an independent kingdom. In 223 BCE, Antiochus III came to power in the Seleucid Empire, one of the Hellenistic states that had emerged following the death of Alexander. Antiochus attacked Atropatene,

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