on 2 June 1859 as one of five Japanese open ports designated in the 1858 Treaty of Amity and Commerce signed with the U.S. The Hakodate foreign settlement is one of the legacies of foreign influence in Hakodate.

A mariner in Perry's fleet died during a visit to the area and became the first U.S. citizen to be buried in Japan when he was interred in Hakodate's cemetery for foreigners.