secret agent who tried to expose his corrupt superiors, only to be betrayed and forced to watch his wife and family being tortured and killed, causing him to develop a split personality.

As they head to the border, a hit is put on Machete, and the two are targeted by multiple assailants including Desdemona and her prostitute assassins, a shapeshifting hitman called El/La Camaleón, Doakes and Clebourne, and various locals. Machete and Mendez evade the assailants,