(who was later created Duke of Parma), Paolo, and Ranuccio. In July 1505, Pope Julius II legitimated the two eldest sons so that they could inherit the Farnese family estates. On 23 June 1513, Pope Leo X published a second legitimation of Pier Luigi, and also legitimized Ranuccio (the second son Paolo had already died).

On 28 March 1509, Alessandro was named Bishop of Parma, but he was not