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that are essential for each individual RNA polymerase (e.g., TFIIA, TFIIB, TFIIE, TFIIF and TFIIH for Pol II, and TFIIIB and TFIIIC for Pol III) to "read" specific target genes.
* 1980: Roeder identifies the first mammalian gene-specific activator, called TFIIIA. TFIIIA and similar proteins bind to specific DNA sequences and enhance the reading of corresponding

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