fuse, resulting in a linear transcript containing exons that, for example, may be derived from genes encoded on two different chromosomes. Trans-splicing is very common in C. elegans
# A splice donor site being joined to a splice acceptor site further upstream in the primary transcript, yielding a circular transcript.

The notion that circularized transcripts are byproducts from imperfect splicing is supported by the low abundance and the lack of sequence conservation of most circRNAs, but has been challenged.

Alu elements impact circRNA splicing

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