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and confusion/somnolence. Case reports that used doses of 0.1mg/kg (maximum of 2mg/dose) repeated every 1-2 minutes (10mg total dose) have shown inconsistent benefit. As the doses used throughout the literature vary, it is difficult to form a conclusion regarding the benefit of naloxone in this setting. The mechanism for naloxone's proposed benefit in clonidine overdose is unclear. Still, it has been suggested that endogenous opioid receptors mediate the sympathetic nervous system

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