ulcers and inflammation near ulcer
* Surgical operation duration over 3 hours
* Surgical incision over 10 cm
* Polymicrobial infections
* Trauma resulting in open fractures or open repair of closed fractures
* Injection drug use
* Hemodialysis

Pathogenesis

In general, microorganisms may infect bone through one or more of the following mechanisms:
* Via the bloodstream (hematogenous) to a distant site - the most common method
** In children, commonly

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