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the pump (i.e., the region of the pump outside the SR), the pump opens. This occurs because ATP (which contains three phosphate groups) releases a single phosphate group (becoming adenosine diphosphate). The released phosphate group then binds to the pump (in the P domain), causing the pump to change shape. This shape change causes the cytosolic side of the pump to open, allowing the two Ca²⁺ to enter. The cytosolic side

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