the synaptonemal complex disappears during the late prophase of meiosis I. It is formed during zygotene.

Cancer

Although synaptonemal complex protein 2 (SYCP2) is a meiotic protein, it is aberrantly and commonly expressed in breast and ovarian cancers. SYCP2 protein expression in these cancers is associated with broad resistance to drugs that induced DNA damage, i.e. DNA damage response

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