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but only 10-33% (clinical penetrance) of them will develop iron overload. Mutations of the HFE gene (homeostatic iron regulator) located on chromosome 6 (responsible for iron regulatory protein hepcidin regulation) are responsible for most cases of hereditary hemochromatosis; 80-90% of cases of hereditary hemochromatosis involve a mutation of this HFE gene; 90-95% in Northern Europe. Non-HFE hereditary hemochromatosis involves mutations in genes coding for the iron regulatory

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