assayed. Variants that are most likely to occur and present as disease-causing have been predicted. Combined with pathogenicity prediction, this application guides research to test the effect of top candidate variants in preparation for novel disease cases.

RAG2 knockout mice

In 1992, a RAG2 knockout mice strain was generated. Since then, it has become a widely used mouse model in immunological research. This mice strain has an inactivated RAG2 gene. Therefore homozygous mice

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