Wise began his film career at RKO as a sound and music editor. In the 1930s, RKO was a budget-minded studio with "a strong work ethic" and "willingness to take artistic risks", which was fortunate for a newcomer to Hollywood such as Wise. At RKO, Wise became an assistant to T.K. Wood, the studio's head sound-effects editor. Wise's first screen credit was a ten-minute short subject called A Trip through Fijiland (1935), which was made from RKO footage salvaged from an abandoned feature film.

As Wise