being expression of nicotinic cholinergic receptors on all myenteric neurons. One receptor that has been targeted for therapeutic reasons has been the 5-hydroxytryptamine (5-HT₄) receptor. Activating this pre-synaptic receptor enhances cholinergic neurotransmission and can stimulate gastrointestinal motility.

The enteric nervous system exhibits taste receptors similar to the ones in the tongue. The taste receptor TAS1R3 and the taste G protein gustducin