has been shown to influence hypothalamic size, even though the study tried to account for it by including non-transsexual male and female controls which, for a variety of medical reasons, had experienced hormone reversal. The neurobiological basis of gender has been questioned in a follow-up study by the same group which found that the sexual dimorphism of the BSTc is not significant until adulthood (approximately 22 years of age) even though epidemiological studies show much earlier presentation of gender issues.

Since somatostatin-expressing