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2-Mercaptoethanol is the organosulfur compound with the formula HOCH₂CH₂SH. It is a colorless liquid. ME or ?ME, as it is commonly abbreviated, is used to reduce disulfide bonds. It is widely used because the hydroxyl group confers solubility in water and lowers the volatility. Due to its diminished vapor pressure, its odor, while unpleasant, is less objectionable than related thiols.

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