The 2021 24 Hours of Spa (also known as the TotalEnergies 24 Hours of Spa for sponsorship reasons) was the 74th running of the 24 Hours of Spa. It took place from 29 July-1 August 2021. The race was part of both the 2021 GT World Challenge Europe Endurance Cup and the 2021 Intercontinental GT Challenge.

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