ArtemisV is planned to be the fourth crewed mission and second lunar landing of the NASA-led Artemis program. The mission is expected to see the first efforts by NASA to begin building a permanent Moon base. as of 03 2026, launch is scheduled for late 2028.

Originally, ArtemisV was proposed as the program's third lunar landing mission, sending an Orion spacecraft with four astronauts to the now-cancelled Lunar Gateway