Handsome Lake Ganyodaiyo' (1735 - 10 August 1815) was a Seneca religious leader of the Iroquois people. He was a half-brother to Cornplanter Gayentwahgeh, a Seneca war chief.

Handsome Lake, a leader and prophet, played a major role in reviving traditional religion among the Haudenosaunee (People of the Longhouse), or Six Nations Iroquois Confederacy. He preached a message that combined traditional Haudenosaunee