The National Hotel was a hotel in Washington, D.C. It was located on the northeastern corner of the intersection of Pennsylvania Avenue and 6th Street NW. John Gadsby had it built in 1826. The hotel was sold to the city in 1929, and it was demolished in 1942.

The hotel was the site from which Solomon Northup was taken in 1841 after he was incapacitated beginning his Twelve Years a Slave.