PR domain containing 16, also known as PRDM16, is a protein which in humans is encoded by the PRDM16 gene.

PRDM16 acts as a transcription coregulator that controls the development of brown adipocytes in brown adipose tissue. Previously, this coregulator was believed to be present only in brown adipose tissue, but more recent studies have shown that PRDM16 is highly expressed in subcutaneous